Linoleic acid passage through the blood-brain barrier and a possible effect of age

It has already been established that the blood-brain barrier is readily crossed by unsaturated fatty acids, while saturated fatty acid transport appears to be protein mediated. When the passage of the fatty acids is tested in vivo by using perfusion buffers containing both linoleate and palmitate in...

Full description

Saved in:
Bibliographic Details
Published in:Neurochemical research 1994-02, Vol.19 (2), p.129-133
Main Authors: AVELLINI, L, TERRACINA, L, GAITI, A
Format: Article
Language:English
Subjects:
Aging - metabolism
Animals
Biological and medical sciences
Blood-Brain Barrier - physiology
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Fundamental and applied biological sciences. Psychology
Linoleic Acid
Linoleic Acids - pharmacokinetics
Palmitates - pharmacokinetics
Perfusion
Rats
Rats, Sprague-Dawley
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has already been established that the blood-brain barrier is readily crossed by unsaturated fatty acids, while saturated fatty acid transport appears to be protein mediated. When the passage of the fatty acids is tested in vivo by using perfusion buffers containing both linoleate and palmitate in different concentrations, linoleate is able to decrease the palmitate passage, while palmitate increases the linoleate passage. These results could be related to the effect of two fatty acids on the ratio between the fatty acids bound to the serum albumin and the free fatty acid pool, which is only available for transport through membranes. However, on the basis of some results obtained with aged rats, the possibility that a relationship may exist between palmitate and linoleate during their passage through the BBB is discussed. Moreover, it seems likely that in aged rats a moderate modification for fatty acids takes place in the BBB.
ISSN:0364-3190
1573-6903
DOI:10.1007/bf00966806