POTENT ANTITUMOR ANTIBIOTIC COMPLEX: PD 114, 759, PD 115, 028, PD 119, 707, and PD 119, 193

Four novel antitumor antibiotics (PD 114, 759, PD 115, 028, PD 119, 707, and PD 119, 193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC val...

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Bibliographic Details
Published in:Journal of antibiotics 1985, Vol.38(10), pp.1337-1343
Main Authors: TUNAC, J. B., GRAHAM, B. D., MAMBER, S. W., DOBSON, W. E., LENZINI, M. D.
Format: Article
Language:English
Subjects:
Actinomycetales - metabolism
Animals
Antibiotics, Antineoplastic - biosynthesis
Antibiotics, Antineoplastic - pharmacology
Biological Products
Fermentation
Leukemia, Experimental - drug therapy
Mice
Mice, Inbred Strains
Microbial Sensitivity Tests
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Summary:Four novel antitumor antibiotics (PD 114, 759, PD 115, 028, PD 119, 707, and PD 119, 193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC values of
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.38.1337