Study on the inhibition of adenosine deaminase

4(R)-(1-Hydroxyethyl)-5-methyl-1-beta-D-ribofuranosylimidazole (10), which contains only the asymmetric alcohol center of the diazepinol ring of the adenosine deaminase inhibitor coformycin (12), is a much less potent inhibitor of the enzyme but still binds to the enzyme about as tightly as the norm...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1985-11, Vol.28 (11), p.1751-1753
Main Authors: Montgomery, John A, Thomas, H. Jeanette, Zell, Alan L, Einsphar, Howard M, Bugg, Charles E
Format: Article
Language:English
Subjects:
Adenosine - metabolism
Adenosine Deaminase - metabolism
Adenosine Deaminase Inhibitors
Animals
Carbohydrates. Nucleosides and nucleotides
Cattle
Chemical Phenomena
Chemistry
Coformycin - pharmacology
Condensed matter: structure, mechanical and thermal properties
Exact sciences and technology
Heterocyclic compounds
Nucleoside Deaminases - antagonists & inhibitors
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Organic compounds
Physics
Preparations and properties
Ribonucleosides - chemical synthesis
Ribonucleosides - metabolism
Ribonucleosides - pharmacology
Structure of solids and liquids
crystallography
Structure of specific crystalline solids
Structure-Activity Relationship
X-Ray Diffraction
Citations: Items that cite this one
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Summary:4(R)-(1-Hydroxyethyl)-5-methyl-1-beta-D-ribofuranosylimidazole (10), which contains only the asymmetric alcohol center of the diazepinol ring of the adenosine deaminase inhibitor coformycin (12), is a much less potent inhibitor of the enzyme but still binds to the enzyme about as tightly as the normal substrate.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00149a037