Is partial deletion of the complement C4 genes associated with sudden infant death ?

The two C4 loci C4A and C4B in 61 cases of sudden infant death (SID), 93 living controls and 7 cases of infectious death were studied. In the SID group 13.1% showed deletion of the C4A gene, while 2.5% of the cases showed deletion of the C4B gene. This was not significantly different from neither th...

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Bibliographic Details
Published in:European journal of pediatrics 1994-04, Vol.153 (4), p.287-290
Main Authors: OPDAL, S. H, VEGE, A, SAUGSTAD, O. D, ROGNUM, T. O
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Base Sequence
Biological and medical sciences
Case-Control Studies
Complement C4a - genetics
Complement C4b - genetics
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Gene Deletion
Humans
Infant
Infant, Newborn
Infection - genetics
Intensive care medicine
Medical sciences
Molecular Sequence Data
Sudden Infant Death - genetics
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Summary:The two C4 loci C4A and C4B in 61 cases of sudden infant death (SID), 93 living controls and 7 cases of infectious death were studied. In the SID group 13.1% showed deletion of the C4A gene, while 2.5% of the cases showed deletion of the C4B gene. This was not significantly different from neither the controls nor the infectious death group. We were not able to confirm that deletion of the C4B gene is associated with SID. However, in the SID group deletion of either the C4A or the C4B gene was associated with signs of infections prior to death (P = 0.035). This observation may indicate that a proportion of SID victims are more vulnerable to infections than other infants.
ISSN:0340-6199
1432-1076
DOI:10.1007/BF01954522