Associations between HLA Frequencies and Pathogenic Features of Human Immunodeficiency Virus Type 1 Infection in Seroconverters from the Amsterdam Cohort of Homosexual Men

HLA-disease associations may be important for understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. Therefore, 106 homosexual men from the Amsterdam Cohort Study on AIDS with a known date of HIV-1 seroconversion were serologically typed for HLA. Several significant...

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Published in:The Journal of infectious diseases 1994-06, Vol.169 (6), p.1244-1249
Main Authors: Klein, Michèl R., Keet, Ireneus P. M., D'Amaro, Joe, Bende, Richard J., Hekman, Antoon, Mesman, Bert, Koot, Maarten, de Waal, Leo P., Coutinho, Roel A., Miedema, Frank
Format: Article
Language:English
Subjects:
AIDS
AIDS/HIV
Biological and medical sciences
Cohort Studies
Follow-Up Studies
HIV 1
HIV Seropositivity - epidemiology
HIV Seropositivity - immunology
HIV Seropositivity - physiopathology
HIV-1 - immunology
HLA antigens
HLA Antigens - analysis
Homosexuality
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Kaposi sarcoma
Lymphocytes
Major Articles
Male
Male homosexuality
Medical sciences
Netherlands - epidemiology
Opportunistic infections
Phenotype
Phenotypes
T lymphocytes
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container_title The Journal of infectious diseases
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creator Klein, Michèl R.
Keet, Ireneus P. M.
D'Amaro, Joe
Bende, Richard J.
Hekman, Antoon
Mesman, Bert
Koot, Maarten
de Waal, Leo P.
Coutinho, Roel A.
Miedema, Frank
description HLA-disease associations may be important for understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. Therefore, 106 homosexual men from the Amsterdam Cohort Study on AIDS with a known date of HIV-1 seroconversion were serologically typed for HLA. Several significant associations between HLA type and pathogenic features of HIV-1 infection were observed: Subjects with fever and skin rash during primary HIV-1 infection showed an increased frequency of HLA-B62 (relative risk [RR], 5.8; P = .005). The frequency of HLA-B35 was increased in subjects with a rapid decline in CD4+ T lymphocytes (RR, 3.2; P = .021). Kaplan-Meier survival analysis revealed a significant association between HLA-B35 and a decrease in CD4+ cells to
doi_str_mv 10.1093/infdis/169.6.1244
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The frequency of HLA-B35 was increased in subjects with a rapid decline in CD4+ T lymphocytes (RR, 3.2; P = .021). Kaplan-Meier survival analysis revealed a significant association between HLA-B35 and a decrease in CD4+ cells to &lt;200/µL (P = .01). The strongest association was found between HLA-DRI and AIDS-related Kaposi's sarcoma (RR, 22.5; P &lt; .001), also confirmed in survival analysis (P = .001). In AIDS patients with only opportunistic infections, increased frequencies of HLA-DR3 (P = .011) and -DQ2 (P = .007) were observed. 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source JSTOR Archival Journals and Primary Sources Collection; Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects AIDS
AIDS/HIV
Biological and medical sciences
Cohort Studies
Follow-Up Studies
HIV 1
HIV Seropositivity - epidemiology
HIV Seropositivity - immunology
HIV Seropositivity - physiopathology
HIV-1 - immunology
HLA antigens
HLA Antigens - analysis
Homosexuality
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Kaposi sarcoma
Lymphocytes
Major Articles
Male
Male homosexuality
Medical sciences
Netherlands - epidemiology
Opportunistic infections
Phenotype
Phenotypes
T lymphocytes
title Associations between HLA Frequencies and Pathogenic Features of Human Immunodeficiency Virus Type 1 Infection in Seroconverters from the Amsterdam Cohort of Homosexual Men
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