Pathogenesis and pharmacologic management of pseudo-obstruction of the bowel in pheochromocytoma

Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointesti...

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Bibliographic Details
Published in:The American journal of the medical sciences 1985-10, Vol.290 (4), p.155-158
Main Authors: MULLEN, J. P, CARTWRIGHT, R. C, TISHERMAN, S. E, MISAGE, J. R, SHAPIRO, A. P
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - metabolism
Adrenergic alpha-Antagonists - therapeutic use
Adrenergic beta-Antagonists - therapeutic use
Adult
Biological and medical sciences
Catecholamines - metabolism
Constipation - drug therapy
Constipation - etiology
Fecal Impaction - etiology
Female
Hormones. Endocrine system
Humans
Intestinal Obstruction - etiology
Intestinal Pseudo-Obstruction - drug therapy
Intestinal Pseudo-Obstruction - etiology
Male
Medical sciences
Pharmacology. Drug treatments
Pheochromocytoma - complications
Pheochromocytoma - metabolism
Pheochromocytoma - secondary
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Summary:Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointestinal manifestations can, on rare occasions, be just as serious and life threatening. We present two patients with metastatic pheochromocytoma who developed pseudo-obstruction, and discuss the pathopharmacology and treatment of this syndrome.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198510000-00004