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Pathogenesis and pharmacologic management of pseudo-obstruction of the bowel in pheochromocytoma
Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointesti...
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| Published in: | The American journal of the medical sciences 1985-10, Vol.290 (4), p.155-158 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 158 |
| container_issue | 4 |
| container_start_page | 155 |
| container_title | The American journal of the medical sciences |
| container_volume | 290 |
| creator | MULLEN, J. P CARTWRIGHT, R. C TISHERMAN, S. E MISAGE, J. R SHAPIRO, A. P |
| description | Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointestinal manifestations can, on rare occasions, be just as serious and life threatening. We present two patients with metastatic pheochromocytoma who developed pseudo-obstruction, and discuss the pathopharmacology and treatment of this syndrome. |
| doi_str_mv | 10.1097/00000441-198510000-00004 |
| format | article |
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P ; CARTWRIGHT, R. C ; TISHERMAN, S. E ; MISAGE, J. R ; SHAPIRO, A. P</creator><creatorcontrib>MULLEN, J. P ; CARTWRIGHT, R. C ; TISHERMAN, S. E ; MISAGE, J. R ; SHAPIRO, A. P</creatorcontrib><description>Metastatic malignant pheochromocytoma can be a disease of long duration and though poorly responsive to both radiation therapy and chemotherapy, pharmacologic management of its myriad manifestations can be very effective. Hypertension is the most recognized feature of this disease, but gastrointestinal manifestations can, on rare occasions, be just as serious and life threatening. We present two patients with metastatic pheochromocytoma who developed pseudo-obstruction, and discuss the pathopharmacology and treatment of this syndrome.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-198510000-00004</identifier><identifier>PMID: 2866712</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adrenal Gland Neoplasms - metabolism ; Adrenergic alpha-Antagonists - therapeutic use ; Adrenergic beta-Antagonists - therapeutic use ; Adult ; Biological and medical sciences ; Catecholamines - metabolism ; Constipation - drug therapy ; Constipation - etiology ; Fecal Impaction - etiology ; Female ; Hormones. Endocrine system ; Humans ; Intestinal Obstruction - etiology ; Intestinal Pseudo-Obstruction - drug therapy ; Intestinal Pseudo-Obstruction - etiology ; Male ; Medical sciences ; Pharmacology. 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We present two patients with metastatic pheochromocytoma who developed pseudo-obstruction, and discuss the pathopharmacology and treatment of this syndrome.</description><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adrenergic alpha-Antagonists - therapeutic use</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Catecholamines - metabolism</subject><subject>Constipation - drug therapy</subject><subject>Constipation - etiology</subject><subject>Fecal Impaction - etiology</subject><subject>Female</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Intestinal Obstruction - etiology</subject><subject>Intestinal Pseudo-Obstruction - drug therapy</subject><subject>Intestinal Pseudo-Obstruction - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pheochromocytoma - complications</subject><subject>Pheochromocytoma - metabolism</subject><subject>Pheochromocytoma - secondary</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNo9kE1PwzAMhiMEGmPwE5B6QNwKcZK2yRFNfEmT4ADnkibuVtQmpUmF9u_poMI-WH7e15ZlQhKgN0BVcUsPIQSkoGQGhyb9JUdkCRmXKVOKHpPlhFiqcqZOyVkIn5QCk8AXZMFknhfAluTjVced36LD0IREO5v0Oz102vjWbxuTdNrpLXboYuLrpA84Wp_6KsRhNLHx7kDjDpPKf2ObNG4aR292g--82Uff6XNyUus24MVcV-T94f5t_ZRuXh6f13ebtGc8iylopLoWKK2h08GsqgsOFVjBLALNqxptXtSVBZ6DtIIqACGF4qpQAjOp-Ipc_-3tB_81Yohl1wSDbasd-jGURZ5RNeVkvJyNY9WhLfuh6fSwL-eXTPrVrOtgdFsP2pkm_NtkRmXBGf8B4d1ycA</recordid><startdate>198510</startdate><enddate>198510</enddate><creator>MULLEN, J. P</creator><creator>CARTWRIGHT, R. C</creator><creator>TISHERMAN, S. E</creator><creator>MISAGE, J. R</creator><creator>SHAPIRO, A. 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Drug treatments</topic><topic>Pheochromocytoma - complications</topic><topic>Pheochromocytoma - metabolism</topic><topic>Pheochromocytoma - secondary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MULLEN, J. P</creatorcontrib><creatorcontrib>CARTWRIGHT, R. C</creatorcontrib><creatorcontrib>TISHERMAN, S. E</creatorcontrib><creatorcontrib>MISAGE, J. R</creatorcontrib><creatorcontrib>SHAPIRO, A. P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MULLEN, J. P</au><au>CARTWRIGHT, R. C</au><au>TISHERMAN, S. 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| fulltext | fulltext |
| identifier | ISSN: 0002-9629 |
| ispartof | The American journal of the medical sciences, 1985-10, Vol.290 (4), p.155-158 |
| issn | 0002-9629 1538-2990 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76509090 |
| source | ScienceDirect Journals |
| subjects | Adrenal Gland Neoplasms - metabolism Adrenergic alpha-Antagonists - therapeutic use Adrenergic beta-Antagonists - therapeutic use Adult Biological and medical sciences Catecholamines - metabolism Constipation - drug therapy Constipation - etiology Fecal Impaction - etiology Female Hormones. Endocrine system Humans Intestinal Obstruction - etiology Intestinal Pseudo-Obstruction - drug therapy Intestinal Pseudo-Obstruction - etiology Male Medical sciences Pharmacology. Drug treatments Pheochromocytoma - complications Pheochromocytoma - metabolism Pheochromocytoma - secondary |
| title | Pathogenesis and pharmacologic management of pseudo-obstruction of the bowel in pheochromocytoma |
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