Recovery after propofol infusion anaesthesia in children : comparison with propofol, thiopentone of halothane induction followed by halothane maintenance

We have compared the recovery profiles of 163 healthy Chinese children after general anaesthesia for minor surgical procedures. Patients were allocated randomly to receive one of four anaesthetic techniques: propofol infusion for induction and maintenance using a pharmacokinetic model-controlled syr...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1994-05, Vol.72 (5), p.554-558
Main Authors: AUN, C. S. T, SHORT, T. G, O'MEARA, M. E, LEUNG, D. H. Y, ROWBOTTOM, Y. M, OH, T. E
Format: Article
Language:English
Subjects:
Anesthesia Recovery Period
Anesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Child
Child, Preschool
Female
Halothane - pharmacology
Humans
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Postoperative Complications
Propofol - pharmacology
Psychomotor Performance - drug effects
Thiopental - pharmacology
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Summary:We have compared the recovery profiles of 163 healthy Chinese children after general anaesthesia for minor surgical procedures. Patients were allocated randomly to receive one of four anaesthetic techniques: propofol infusion for induction and maintenance using a pharmacokinetic model-controlled syringe pump set initially at a target concentration of 8 micrograms ml-1 and then adjusted according to clinical requirements; propofol 2.5-3.5 mg kg-1, thiopentone 4-5 mg kg-1 or 2-3% halothane for induction of anaesthesia followed by 1-2% halothane for maintenance of anaesthesia. All patients breathed a mixture of 70% nitrous oxide in oxygen through a laryngeal mask airway and received an appropriate regional anaesthetic block. Recovery was assessed using the time to achieve full Steward score, open eyes on command, orientation and the time required to complete a simple puzzle. Recovery was slowest with the propofol infusion (mean 39.8 (SD 12.9) min when eyes opened on command). The recovery times were significantly shorter with the three other techniques (propofol bolus 21.9 (9.9) min, thiopentone 23.4 (11.3) min, halothane 20.1 (8.9) min), and the choice among these three methods had no significant influence on the recovery profile.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/72.5.554