Serum interleukin-6 concentration in schizophrenia: Elevation associated with duration of illness

Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the cont...

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Bibliographic Details
Published in:Psychiatry research 1994, Vol.51 (1), p.1-10
Main Authors: Ganguli, Rohan, Yang, Zanwei, Shurin, Galina, Chengappa, K.N.Roy, Brar, Jaspreet S., Gubbi, Amanda V., Rabin, Bruce S.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - therapeutic use
Autoantibodies
Autoantibodies - immunology
Biological and medical sciences
cytokine
Cytokines - immunology
Ethnic Groups
Female
Humans
Interleukin-6 - blood
Interleukin-6 - immunology
Male
Medical sciences
psychoimmunology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - blood
Schizophrenia - drug therapy
Schizophrenia - immunology
Sex Factors
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Summary:Using an enzyme immunoassay (ELISA), we measured serum interleukin-6 (IL-6) concentration in 128 schizophrenic patients (24 of whom were never medicated) and in 110 normal control subjects. Mean serum IL-6 concentration was significantly higher in the schizophrenic patients as compared with the control subjects ( p = 0.009). Comparisons within the patient group revealed that serum IL-6 was significantly correlated with duration of illness ( r = 0.32, p = 0.0004). After covariation for duration of illness, there was no relationship between IL-6 levels and the production of autoantibodies, clinical state, or medication status. Thus, elevated serum IL-6 levels in schizophrenia develop during the course of illness and may be related to treatment or to disease progression.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(94)90042-6