On the change of cardiac action potential with age: a study in dogs

The action potential duration (APD) was measured using an Ag-AgCl electrode, in open chest anaesthetised dogs (n = 8) and puppies, 4 to 6 months old (n=8), with complete atrio-ventricular dissociation and β-adrenergic blockade. They were paced in the control period at a frequency of 120 beats·min−1....

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Bibliographic Details
Published in:Cardiovascular research 1985-11, Vol.19 (11), p.674-678
Main Authors: BOSKER, HANS, DRAKE-HOLLAND, ANGELA J, KEURS, HENK E D J TER, NOBLE, MARK I M, PASSINGHAM, JANE E, PEPPER, JOHN R, MAIN, MARK J, WANLESS, RICHARD B
Format: Article
Language:English
Subjects:
action potential duration
Action Potentials
Aging
Animals
Biological and medical sciences
Dogs
Fundamental and applied biological sciences. Psychology
Heart
Heart - physiology
puppy vs dog
sodium pump
Time Factors
Vertebrates: cardiovascular system
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Summary:The action potential duration (APD) was measured using an Ag-AgCl electrode, in open chest anaesthetised dogs (n = 8) and puppies, 4 to 6 months old (n=8), with complete atrio-ventricular dissociation and β-adrenergic blockade. They were paced in the control period at a frequency of 120 beats·min−1. Both adults and puppies showed maximum action potential duration at a test pulse interval of over 700 ms. Below this the adult dogs showed a progressive shortening of the action potential duration (mean APD 81.5% at 200 ms). In contrast, the puppies showed much less shortening (91% at 200 ms; p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/19.11.674