Anti-inflammatory Activities of Methanolic Extract and Alkaloidal Components from Corydalis Tuber

A methanolic extract (CM-ext) from Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. HSU) has been screened for activity in experimental models of inflammation. CM-ext (200 or 500 mg/kg, p.o.) inhibited an increase in vascular permeability in mice induced by acetic...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1994/02/15, Vol.17(2), pp.262-265
Main Authors: KUBO, Michinori, MATSUDA, Hideaki, TOKUOKA, Kiyoshi, MA, Shiping, SHIOMOTO, Hidemi
Format: Article
Language:English
Subjects:
alkaloid
Alkaloids - pharmacology
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Aporphines - pharmacology
Arthritis, Experimental - drug therapy
Berberine Alkaloids - pharmacology
Biological and medical sciences
Capillary Permeability - drug effects
Corydalis turtschaninovii forma yanhusuo
d-glaucine
dehydrocorydaline
Drugs, Chinese Herbal - pharmacology
Edema - drug therapy
Female
General pharmacology
Guinea Pigs
Histamine Release - drug effects
Ileum - drug effects
In Vitro Techniques
inflammation
Inflammation - drug therapy
l-tetra-hydrocoptisine
Male
Medical sciences
Methanol - chemistry
Mice
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Rats, Wistar
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Summary:A methanolic extract (CM-ext) from Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. HSU) has been screened for activity in experimental models of inflammation. CM-ext (200 or 500 mg/kg, p.o.) inhibited an increase in vascular permeability in mice induced by acetic acid, and reduced acute paw edema in rats induced by compound 48/80 or carrageenin. CM-ext suppressed the development of adjuvant-induced edema in arthritic rats. CM-ext and its alkaloidal components, dehydrocorydaline, d-glaucine and l-tetra-hydrocoptisine inhibited compound 48/80-induced histamine release from peritoneal mast cells of rats. Since these substances from C. tuber were found to be effective in both the acute and chronic phases of inflammation, the crude drug C. tuber can be considered to exert anti-inflammatory activity.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.17.262