Chromatographic studies of the enantiomeric composition of some therapeutic compositions applied in the treatment of liver and kidney diseases

A gas-liquid chromatographic system with α-cyclodextrin in formamide medium (coated on Chromosorb) was used for the separation of enantiomers of α-pinene, β-pinene, limonene and camphene in medicines applied in the therapy of liver and kidney diseases. The drugs under investigation were produced in...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Chromatography A 1994-04, Vol.665 (1), p.67-73
Main Authors: Sybilska, Danuta, Kowalczyk, Joanna, Asztemborska, Monika, Ochocka, Renata J., Lamparczyk, Henryk
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Bridged Bicyclo Compounds - chemistry
Bridged Bicyclo Compounds - isolation & purification
Bridged Bicyclo Compounds - therapeutic use
Chromatography, Gas
Cyclohexenes
Drug Combinations
Flame Ionization
General pharmacology
Humans
Kidney Diseases - drug therapy
Liver Diseases - drug therapy
Medical sciences
Monoterpenes
Pharmacology. Drug treatments
Stereoisomerism
Terpenes - chemistry
Terpenes - isolation & purification
Terpenes - therapeutic use
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A gas-liquid chromatographic system with α-cyclodextrin in formamide medium (coated on Chromosorb) was used for the separation of enantiomers of α-pinene, β-pinene, limonene and camphene in medicines applied in the therapy of liver and kidney diseases. The drugs under investigation were produced in Poland (Terpichol and Terpinex), in Germany (Rowachol and Rowatinex) and in Slovenia (Uroterp). It was found that, depending on the manufacturer, medicines possessing similar chemical compositions differ considerably from one another regarding the content of enantiomers, mainly those of α-pinene.
ISSN:0021-9673
DOI:10.1016/0021-9673(94)87033-0