Elevated Serum Insulin Levels in Patients With Essential Hypertension and Microalbuminuria

Hyperinsulinemia, insulin resistance, or both have been described in patients with essential hypertension. Previous work from our laboratory has shown that in hypertensive patients with microalbuminuria, dyslipidemia and abnormal patterns in the diurnal variations of blood pressure are frequently as...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-06, Vol.23 (6, Part 1), p.681-687
Main Authors: Bianchi, Stefano, Bigazzi, Roberto, Valtriani, Carla, Chiapponi, Ivo, Sgherri, Gianpaolo, Baldari, Giorgio, Natali, Andrea, Ferrannini, Eleuterio, Campese, Vito M
Format: Article
Language:English
Subjects:
Adult
Albuminuria - etiology
Antihypertensive agents
Biological and medical sciences
Blood Pressure
Cardiovascular system
Circadian Rhythm
Female
Glucose - pharmacology
Humans
Hyperinsulinism - etiology
Hypertension - blood
Hypertension - complications
Hypertension - physiopathology
Insulin - blood
Lipids - blood
Male
Medical sciences
Pharmacology. Drug treatments
Reference Values
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hyperinsulinemia, insulin resistance, or both have been described in patients with essential hypertension. Previous work from our laboratory has shown that in hypertensive patients with microalbuminuria, dyslipidemia and abnormal patterns in the diurnal variations of blood pressure are frequently associated. Whether hyperinsulinemia and microalbuminuria are directly related has not been determined. To test this possibility, we measured the plasma insulin response to an oral glucose load in 25 patients with or without microalbuminuria and 20 normotensive control subjects. Serum lipid profile and 24-hour ambulatory blood pressure were obtained. In the hypertensive patients as a group, the plasma insulin response to glucose (evaluated as the insulin area under the curve) was significantly enhanced compared with a group of 20 normotensive healthy control subjects (46 311±3745 and 27 557±2563 pmol/L×2 hours, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.23.6.681