The effects of naloxone on opiate and placebo analgesia in healthy volunteers

Two double blind cross-over studies were performed using a submaximal effort tourniquet test (SETT) in healthy volunteers to investigate the role of endogenous opioids in placebo analgesia. In the first study IV naloxone significantly inhibited analgesia, miosis and sedation produced by the opioid d...

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Bibliographic Details
Published in:Psychopharmacologia 1985-01, Vol.87 (4), p.468-472
Main Authors: POSNER, J, BURKE, C. A
Format: Article
Language:English
Subjects:
Adult
Analgesia
Analgesics
Analgesics, Opioid - therapeutic use
Biological and medical sciences
Codeine - therapeutic use
Endorphins - physiology
Female
Humans
Male
Medical sciences
Methadone - analogs & derivatives
Methadone - therapeutic use
Middle Aged
Naloxone
Neuropharmacology
Pain - physiopathology
Pain Management
Pharmacology. Drug treatments
Placebos
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Summary:Two double blind cross-over studies were performed using a submaximal effort tourniquet test (SETT) in healthy volunteers to investigate the role of endogenous opioids in placebo analgesia. In the first study IV naloxone significantly inhibited analgesia, miosis and sedation produced by the opioid dipipanone 10 mg in 12 subjects. In the second naloxone, which did not produce hyperalgesia, failed to inhibit significant placebo analgesia in 12 subjects. The results do not support the involvement of endogenous opioids in ischemic limb pain or placebo analgesia under these conditions.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00432515