Anergic T Cells as Suppressor Cells in Vitro

T cell-mediated suppression is an established phenomenon, but its underlying mechanisms are obscure. An in vitro system was used to test the possibility that anergic T cells can act as specific suppressor cells. Anergic human T cells caused inhibition of antigen-specific and allospecific T cell prol...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-06, Vol.264 (5165), p.1587-1589
Main Authors: Lombardi, Giovanna, Sidhu, Sid, Batchelor, Richard, Lechler, Robert
Format: Article
Language:English
Subjects:
Antibodies
Antigen-Presenting Cells - immunology
Antigens
B lymphocytes
Biological and medical sciences
Cell Line
Cells, Cultured
Cellular biology
Clonal Anergy
Competition
Cultured cells
Cytokines
Exercise tolerance
Feedback (Response)
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunity (Disease)
Immunobiology
Inhibition
Interleukin-10 - immunology
Interleukin-2 - immunology
Interleukin-2 - metabolism
Interleukin-4 - immunology
Ligands
Logical Thinking
Lymphocyte Activation
Modulation of the immune response (stimulation, suppression)
Physiological aspects
Recombinant Proteins - immunology
Suppressor cells
T cells
T lymphocytes
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Regulatory - immunology
Transforming Growth Factor beta - immunology
Transplantation tolerance
Transponders
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Summary:T cell-mediated suppression is an established phenomenon, but its underlying mechanisms are obscure. An in vitro system was used to test the possibility that anergic T cells can act as specific suppressor cells. Anergic human T cells caused inhibition of antigen-specific and allospecific T cell proliferation. In order for the inhibition to occur, the anergic T cells had to be specific for the same antigen-presenting cells (APCs) as the T cells that were suppressed. The mechanism of this suppression appears to be competition for the APC surface and for locally produced interleukin-2.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8202711