Protection of mice against Clostridium chauvoei infection by anti-idiotype antibody to a monoclonal antibody to flagella

Polyclonal rabbit anti-idiotypic antibody (anti-Id) against the protective monoclonal antibody specific to the flagella of Clostridium chauvoei was produced, purified, and characterized. Anti-Id inhibited the binding of its related monoclonal antibody to the flagellar antigen, suggesting that the an...

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Bibliographic Details
Published in:FEMS immunology and medical microbiology 1994-03, Vol.8 (3), p.183-187
Main Authors: Kijima-Tanaka, M, Nakamura, M, Nagamine, N, Takahashi, T, Aoki, A, Tamura, Y
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
antibodies
Antibodies, Anti-Idiotypic - therapeutic use
Antibodies, Bacterial - immunology
Antibodies, Monoclonal
Antibody production
antigens
Anti‐idiotypic antibody
Biological and medical sciences
Clostridium - immunology
Clostridium - pathogenicity
Clostridium chauvoei
Clostridium Infections - prevention & control
Enzyme-Linked Immunosorbent Assay
Flagella
Flagella - immunology
flagellum
Fundamental and applied biological sciences. Psychology
Fundamental immunology
idiotypes
immunity
Immunization
Immunobiology
Immunogenicity
Immunoglobulin M - immunology
infection
Mice
Mice, Inbred Strains
monoclonal antibodies
Monoclonal antibody
vaccination
vaccines
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Description
Summary:Polyclonal rabbit anti-idiotypic antibody (anti-Id) against the protective monoclonal antibody specific to the flagella of Clostridium chauvoei was produced, purified, and characterized. Anti-Id inhibited the binding of its related monoclonal antibody to the flagellar antigen, suggesting that the anti-Id bore an internal image of the flagellar antigen. When mice were immunized with anti-Id intraperitoneally, the survival rate increased significantly, compared with mice immunized with normal rabbit IgG (P < 0.01), and specific anti-flagellar antibodies were induced.
ISSN:0928-8244
1574-695X
DOI:10.1111/j.1574-695X.1994.tb00441.x