Attempted acceleration of the onset of action pancuronium: effects of divided doses in infants and children

The study was designed to determine whether the onset of action of pancuronium in infants and children could be accelerated by its administration in divided doses. Sixty paediatric patients (0-1 yr (n = 20); 1-3 yr (n = 20); 3-10 yr (n = 20)) were studied during nitrous oxide-oxygen-halothane anaest...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1985-12, Vol.57 (12), p.1204-1208
Main Authors: BEVAN, J. C, DONATI, F, BEVAN, D. R
Format: Article
Language:English
Subjects:
Anesthesia, Inhalation
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Child
Child, Preschool
Drug Administration Schedule
Humans
Infant
Medical sciences
Neuromuscular Junction - physiology
Neuropharmacology
Pancuronium - administration & dosage
Pancuronium - pharmacology
Pharmacology. Drug treatments
Synaptic Transmission - drug effects
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Summary:The study was designed to determine whether the onset of action of pancuronium in infants and children could be accelerated by its administration in divided doses. Sixty paediatric patients (0-1 yr (n = 20); 1-3 yr (n = 20); 3-10 yr (n = 20)) were studied during nitrous oxide-oxygen-halothane anaesthesia using train-of-four stimulation, and the results were compared with data obtained previously in adults. The time to onset correlated with the patient's age, and an additional, small acceleration was produced following divided doses which did not alter the duration or pattern of neuromuscular blockade. It was concluded that, in children, divided doses of pancuronium are unlikely to offer important clinical advantages.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/57.12.1204