Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus

To find the dominant epitopes of a major autoantigen in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD), we studied the reactivity of peripheral blood T lymphocytes with peptides covering both major isoforms. A significant response to GAD 65 or GAD 67 peptides was detec...

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Bibliographic Details
Published in:The Lancet (British edition) 1994-06, Vol.343 (8913), p.1607-1608
Main Authors: Lohmann, T., Londei, M., Leslie, R.D.G., Hawa, M., Geysen, M., Rodda, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autoantigens - immunology
Biochemistry
Child
Child, Preschool
Diabetes
Diabetes Mellitus, Type 1 - immunology
Glutamate Decarboxylase - immunology
Humans
Immunity (Disease)
Immunodominant Epitopes - analysis
Insulin
Lymphocytes
Medical research
Middle Aged
Peptides
T-Lymphocytes - immunology
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Summary:To find the dominant epitopes of a major autoantigen in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD), we studied the reactivity of peripheral blood T lymphocytes with peptides covering both major isoforms. A significant response to GAD 65 or GAD 67 peptides was detected in 13 of 15 IDDM patients and in 9 of 10 normal controls. Controls most frequently recognised the central region of GAD 65 (residues 161-243). IDDM patients preferentially recognised residues 473-555 (p
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(94)93061-9