Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle

To investigate an apoptotic role for bcl-2 in menses, we studied bcl-2 protein production throughout the cycle. Bcl-2 protein was observed in endometrial glandular, stromal and myometrial smooth-muscle cells. Glandular cells expressed bcl-2 at proliferative through early secretory phases but not at...

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Bibliographic Details
Published in:The Lancet (British edition) 1994-07, Vol.344 (8914), p.28-29
Main Authors: OTSUKI, Y, MISAKI, O, SUGIMOTO, O, ITO, Y, TSUJIMOTO, Y, AKAO, Y
Format: Article
Language:English
Subjects:
Apoptosis - genetics
Biochemistry
Biological and medical sciences
Blotting, Western
Endometrium - metabolism
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Hormone metabolism and regulation
Hormones
Humans
Immunohistochemistry
Mammalian female genital system
Medical research
Menstrual Cycle - genetics
Menstrual Cycle - metabolism
Menstruation
Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Receptors, Estrogen - analysis
Receptors, Progesterone - analysis
Vertebrates: reproduction
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Summary:To investigate an apoptotic role for bcl-2 in menses, we studied bcl-2 protein production throughout the cycle. Bcl-2 protein was observed in endometrial glandular, stromal and myometrial smooth-muscle cells. Glandular cells expressed bcl-2 at proliferative through early secretory phases but not at late secretory through menstrual phases. This cyclic expression of bcl-2 gene was similar to that of oestrogen and progesterone receptors. Thus bcl-2 expression in glandular cells may be regulated by ovarian hormones. The disappearance of bcl-2 expression in glandular cells at late secretory phase was consistent with the appearance of apoptotic cells in the same phase.
ISSN:0140-6736
1474-547X