Are Granulocytes the Main Effector Cells of Natural Cytotoxicity in Chickens?

Purified peripheral blood granulocytes from chicken were tested for cytotoxic activity against two types of virus-transformed chicken cell line, LSCC-H32 and LSCC-RP9. Strong cytotoxicity could be demonstrated, as measured in a 4-hr 51Cr-release assay, especially against the fibroblastoid LSCC-H32 c...

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Bibliographic Details
Published in:Immunobiology (1979) 1985-11, Vol.170 (4), p.284-292
Main Authors: Mándi, Yvette, Seprényi, G, Pusztai, Rozália, Béládi, Ilona
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Animals
Biological and medical sciences
Chick Embryo
chickens
Chickens - immunology
cytotoxicity
Cytotoxicity, Immunologic
Fibroblasts - immunology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
granulocytes
Granulocytes - immunology
Humans
Immunity, Innate
Immunobiology
In Vitro Techniques
Killer Cells, Natural - immunology
natural cytotoxicity
neoplasms
Organs and cells involved in the immune response
Species Specificity
spleen
Spleen - immunology
virus associated lymphoid tumors
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Summary:Purified peripheral blood granulocytes from chicken were tested for cytotoxic activity against two types of virus-transformed chicken cell line, LSCC-H32 and LSCC-RP9. Strong cytotoxicity could be demonstrated, as measured in a 4-hr 51Cr-release assay, especially against the fibroblastoid LSCC-H32 cells. The degree of cytotoxicity was dependent on the E:T ratio. Normal CEF cells were completely resistant to the cytotoxicity. No cytotoxicity of human granulocytes could be observed against a variety of adherent and non-adherent target cells, as measured by the same microcytotoxicity technique. The priority of granulocytes in the natural cytotoxicity in the avian system is, therefore, suggested.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(85)80077-2