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Are Granulocytes the Main Effector Cells of Natural Cytotoxicity in Chickens?
Purified peripheral blood granulocytes from chicken were tested for cytotoxic activity against two types of virus-transformed chicken cell line, LSCC-H32 and LSCC-RP9. Strong cytotoxicity could be demonstrated, as measured in a 4-hr 51Cr-release assay, especially against the fibroblastoid LSCC-H32 c...
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| Published in: | Immunobiology (1979) 1985-11, Vol.170 (4), p.284-292 |
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| Main Authors: | , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c328t-1b18d301fa4f7587d416a2a9ac4ac3b346856eb20617d9f0618dac6a07fd863d3 |
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| cites | cdi_FETCH-LOGICAL-c328t-1b18d301fa4f7587d416a2a9ac4ac3b346856eb20617d9f0618dac6a07fd863d3 |
| container_end_page | 292 |
| container_issue | 4 |
| container_start_page | 284 |
| container_title | Immunobiology (1979) |
| container_volume | 170 |
| creator | Mándi, Yvette Seprényi, G Pusztai, Rozália Béládi, Ilona |
| description | Purified peripheral blood granulocytes from chicken were tested for cytotoxic activity against two types of virus-transformed chicken cell line, LSCC-H32 and LSCC-RP9. Strong cytotoxicity could be demonstrated, as measured in a 4-hr
51Cr-release assay, especially against the fibroblastoid LSCC-H32 cells. The degree of cytotoxicity was dependent on the E:T ratio. Normal CEF cells were completely resistant to the cytotoxicity. No cytotoxicity of human granulocytes could be observed against a variety of adherent and non-adherent target cells, as measured by the same microcytotoxicity technique. The priority of granulocytes in the natural cytotoxicity in the avian system is, therefore, suggested. |
| doi_str_mv | 10.1016/S0171-2985(85)80077-2 |
| format | article |
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Psychology</subject><subject>Fundamental immunology</subject><subject>granulocytes</subject><subject>Granulocytes - immunology</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Immunobiology</subject><subject>In Vitro Techniques</subject><subject>Killer Cells, Natural - immunology</subject><subject>natural cytotoxicity</subject><subject>neoplasms</subject><subject>Organs and cells involved in the immune response</subject><subject>Species Specificity</subject><subject>spleen</subject><subject>Spleen - immunology</subject><subject>virus associated lymphoid tumors</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqFkEtv1DAQgC0EKkvhJ1T4gBAcUvyIY-dUVVFpkVo4lJ6tWT-oIRu3toPYf1-HXe210khzmG9eH0InlJxSQrsvt4RK2rBeiU9KfFaESNmwF2hFlVQNZ7J_iVYH5DV6k_NvQmjPpDpCRy1RHWn5Ct2cJ4cvE0zzGM22uIzLvcM3ECZ84b0zJSY8uHHMOHr8HcqcYMTDtsQS_wUTyhZXcrgP5o-b8tlb9MrDmN27fT5Gd18vfg5XzfWPy2_D-XVjOFOloWuqLCfUQ-ulUNK2tAMGPZgWDF_ztlOic2tGOipt72tSFkwHRHqrOm75Mfq4m_uQ4uPsctGbkE09EyYX56xlJ6Tkvaig2IEmxZyT8_ohhQ2kraZELxr1f416caSXWDRqVvtO9gvm9cbZQ9feW61_2NchGxh9FWhCPmCyJ4SJZcz7HeYhaviVKnJ3ywitv7eCilZW4mxHuKrrb3BJZxPcZJwNqdrXNoZnTn0CQDSW-g</recordid><startdate>198511</startdate><enddate>198511</enddate><creator>Mándi, Yvette</creator><creator>Seprényi, G</creator><creator>Pusztai, Rozália</creator><creator>Béládi, Ilona</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198511</creationdate><title>Are Granulocytes the Main Effector Cells of Natural Cytotoxicity in Chickens?</title><author>Mándi, Yvette ; Seprényi, G ; Pusztai, Rozália ; Béládi, Ilona</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-1b18d301fa4f7587d416a2a9ac4ac3b346856eb20617d9f0618dac6a07fd863d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chick Embryo</topic><topic>chickens</topic><topic>Chickens - immunology</topic><topic>cytotoxicity</topic><topic>Cytotoxicity, Immunologic</topic><topic>Fibroblasts - immunology</topic><topic>Fundamental and applied biological sciences. 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51Cr-release assay, especially against the fibroblastoid LSCC-H32 cells. The degree of cytotoxicity was dependent on the E:T ratio. Normal CEF cells were completely resistant to the cytotoxicity. No cytotoxicity of human granulocytes could be observed against a variety of adherent and non-adherent target cells, as measured by the same microcytotoxicity technique. The priority of granulocytes in the natural cytotoxicity in the avian system is, therefore, suggested.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>4086043</pmid><doi>10.1016/S0171-2985(85)80077-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | Immunobiology (1979), 1985-11, Vol.170 (4), p.284-292 |
| issn | 0171-2985 1878-3279 |
| language | eng |
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| source | ScienceDirect® |
| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Chick Embryo chickens Chickens - immunology cytotoxicity Cytotoxicity, Immunologic Fibroblasts - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology granulocytes Granulocytes - immunology Humans Immunity, Innate Immunobiology In Vitro Techniques Killer Cells, Natural - immunology natural cytotoxicity neoplasms Organs and cells involved in the immune response Species Specificity spleen Spleen - immunology virus associated lymphoid tumors |
| title | Are Granulocytes the Main Effector Cells of Natural Cytotoxicity in Chickens? |
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