Mycoplasma pulmonis Arthritis in Mice: Microbiological and Immunological Features

Mycoplasma pulmonis m53 was inoculated intraarticularly in the bilateral hind footpads and bilateral knee joints of BALB/c mice. Mycoplasmas were recovered from the affected joints over 20 weeks accompanying acute or subacute inflammation. Intensive deposition of immunoglobulins, a complement (C3) a...

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Bibliographic Details
Published in:MICROBIOLOGY and IMMUNOLOGY 1985, Vol.29(7), pp.645-657
Main Authors: Kono, Masako, Yoshioka, Morimasa, Imai, Miki, Hirose, Shunichi
Format: Article
Language:English
Subjects:
Animals
Antigen-Antibody Complex - immunology
Antigens, Bacterial - analysis
Arthritis, Infectious - immunology
Arthritis, Infectious - microbiology
Arthritis, Infectious - pathology
Bacterial diseases
Biological and medical sciences
Complement System Proteins - analysis
Experimental bacterial diseases and models
Immunoglobulins - analysis
Infectious diseases
Male
Medical sciences
Mice
Mice, Inbred BALB C
Mycoplasma Infections - immunology
Mycoplasma Infections - microbiology
Mycoplasma Infections - pathology
Mycoplasma pulmonis
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Summary:Mycoplasma pulmonis m53 was inoculated intraarticularly in the bilateral hind footpads and bilateral knee joints of BALB/c mice. Mycoplasmas were recovered from the affected joints over 20 weeks accompanying acute or subacute inflammation. Intensive deposition of immunoglobulins, a complement (C3) and mycoplasma cell antigens occurred in synovial and adjacent connective tissues. The histopathologically intact kidneys, brain, and lungs showed deposition of IgG and the complement on the endothelial cells of blood vessels. An IgG-rheumatoid factor like substance (RFLS) was detected in the serum of the mice by an enzyme-linked immunoabsorbent assay. Persistence of mycoplasma cells and immune complexes in the articular tissues might cause the prolongation of inflammatory responses in murine mycoplasmal arthritis.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1985.tb00868.x