Effect of Magnesium Sulfate Infusion on Circulating Levels of Noradrenaline and Neuropeptide-Y-Like Immunoreactivity in Patients with Primary Raynaud's Phenomenon

The effect of a short-term magnesium sulfate (MgSO4) infusion on venous plasma concen tration of noradrenaline (NA) and neuropeptide-Y-like immunoreactivity (NPY-LI) was investigated in 12 women with primary Raynaud's phenomenon (PRP) and in 12 healthy matched controls. The Raynaud's patie...

Full description

Saved in:
Bibliographic Details
Published in:Angiology 1994-07, Vol.45 (7), p.637-645
Main Authors: Leppert, Jerzy, Myrdal, Urban, Hedner, Thomas, Edvinsson, Lars, Tracz, Zofia, Ringqvist, Ivar
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Cold Temperature
Erythrocytes - chemistry
Female
Humans
Infusions, Intravenous
Magnesium - blood
Magnesium Sulfate - administration & dosage
Magnesium Sulfate - pharmacology
Medical sciences
Middle Aged
Miscellaneous
Neuropeptide Y - blood
Norepinephrine - blood
Pharmacology. Drug treatments
Raynaud Disease - blood
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of a short-term magnesium sulfate (MgSO4) infusion on venous plasma concen tration of noradrenaline (NA) and neuropeptide-Y-like immunoreactivity (NPY-LI) was investigated in 12 women with primary Raynaud's phenomenon (PRP) and in 12 healthy matched controls. The Raynaud's patients did not demonstrate any significant changes in mean basal plasma NA concentration (0.29 ±0.15 vs 0.37 ±0.09 ng/mL, ns) after MgSO4 infusion. However, in the controls there was more than twice the amount of circulating nora drenaline (cNA) (0.21 ±0.14 vs 0.54 ±0.22 ng/mL, P < 0.001) after MgSO4 infusion, compared with the preinfusion value. Measurements during the cold pressor test prior to the MgSO4 infusion showed a significant increase of cNA in both the PRP group and the control group (from 0.29 ±0.15 to 0.33 ±0.16 ng/mL, P < 0.05, and from 0.21 ±0.14 to 0.29 ±0.16 ng/mL, P < 0.005, respectively). After MgSO4 infusion the levels of cNA during the cold pressor test increased significantly only in the PRP group (from 0.37 ±0.09 to 0.41 ±0.11 ng/mL, P < 0.05). Circulating NPY-LI concentrations increased significantly during MgSO4 infusion in the Raynaud's patients as well as in the controls from 105 ±21 to 127 ±23 pmol/L, P
ISSN:0003-3197
1940-1574
DOI:10.1177/000331979404500707