Bioactive Annonaceous Acetogenins from the Bark of Xylopia aromatica

Bioactive Annonaceous acetogenins have been isolated from the EtOH extract of the bark of Xylopia aromatica by bioactivity-directed fractionation using lethality to brine shrimp. These acetogenins include xylopianin [1 , xylopiacin [2], and xylomaticin [3], which are three new mono-tetrahydrofuran r...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1994-04, Vol.57 (4), p.486-493
Main Authors: Colman-Saizarbitoria, T, Zambrano, J, Ferrigni, N. R, Gu, Z.-M, Ng, J. H, Smith, D. L, McLaughlin, J. L
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
Animals
annomontacin
ANNONACEAE
annonacin
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Artemia
BARK PRODUCTS
Biological and medical sciences
CHEMICAL COMPOSITION
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
Doxorubicin - pharmacology
DRUG PLANTS
Drug Screening Assays, Antitumor
ESPECTROMETRIA
Furans - isolation & purification
Furans - pharmacology
Gas Chromatography-Mass Spectrometry
General pharmacology
gigantetrocin a
gigantetronenin
Humans
Magnetic Resonance Spectroscopy
Medical sciences
MEDICAMENT CYTOSTATIQUE
MEDICINAL PLANTS
MOLECULAR CONFORMATION
molecular structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
PHYTOTOXINS
PLANTAS MEDICINALES
PLANTE MEDICINALE
Plants, Medicinal - chemistry
PRODUIT A BASE D'ECORCE
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
TOXINAS
TOXINE
TOXINS
TROZOS DE CORTEZA
Tumor Cells, Cultured
Venezuela
xylomaticin
xylopiacin
xylopianin
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bioactive Annonaceous acetogenins have been isolated from the EtOH extract of the bark of Xylopia aromatica by bioactivity-directed fractionation using lethality to brine shrimp. These acetogenins include xylopianin [1 , xylopiacin [2], and xylomaticin [3], which are three new mono-tetrahydrofuran ring type acetogenins, in addition to the known compounds, annomontacin, gigantetronenin, gigantetrocin A, and annonacin. Compounds 1 and 2 are unusual in having hydroxylation at C-8; 3 has the same functionalities as annonacin but with 37 carbons instead of 35 carbons. The structures were elucidated by spectral analysis of the parent compounds and/or simple chemical derivatives. These acetogenins showed cytotoxicities, comparable to adriamycin, against three human solid tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50106a007