Paromomycin for Cryptosporidiosis in AIDS: A Prospective, Double-Blind Trial

To test the effects of paromomycin, 10 patients with AIDS and cryptosporidiosis were randomized to paromomycin or placebo in a double-blind trial. After 14 days, patients were switched to the other treatment for 14 additional days. Measures included the number and character of each stool and weekly...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-08, Vol.170 (2), p.419-424
Main Authors: Clinton White Jr, A., Chappell, Cynthia L., Sikander Hayat, C., Kimball, Kay T., Flanigan, Timothy P., Goodgame, Richard W.
Format: Article
Language:English
Subjects:
Adult
AIDS
AIDS-Related Opportunistic Infections - drug therapy
AIDS/HIV
Cryptosporidiosis
Cryptosporidiosis - drug therapy
Cryptosporidium parvum
Diarrhea
Diarrhea - drug therapy
Double-Blind Method
Excretion
Feces - parasitology
Humans
Infections
Internships
Longitudinal Studies
Major Articles
Oocysts
Parasite Egg Count
Parasitism
Paromomycin - therapeutic use
Placebos
Prospective Studies
Statistical median
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Summary:To test the effects of paromomycin, 10 patients with AIDS and cryptosporidiosis were randomized to paromomycin or placebo in a double-blind trial. After 14 days, patients were switched to the other treatment for 14 additional days. Measures included the number and character of each stool and weekly 24-h stool specimens for weight and oocyst excretion. During the paromomycin treatment phase, oocyst excretion decreased from 314 X 106 to 109 X 106 /24 h (P < .02). Oocyst excretion increased for the 4 patients initially on placebo compared to a median decrease of 128 X 106 /24 h for the 6 initially treated with drug (P < .02). Stool frequency also decreased more in those treated with drug (3.6 fewer vs. 1.25 fewer/24 h, P < .05). Trends favored drug over placebo for stool weight, stool character, and Karnofsky score. Paromomycin treatment resulted in improvement in both clinical and parasitologic parameters in cryptosporidiosis in AIDS.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/170.2.419