Mitochondrial calcium spiking: A transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling

We report reversible Ca 2+-induced Ca 2+ release from mitochondria, which takes the form of Ca 2+ spikes. Mitochondrial Ca 2+ spiking is an all-or-none process with a threshold dependence on both the frequency and the amplitude of the Ca 2+ pulses used as stimuli. This spiking relies on the transien...

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Bibliographic Details
Published in:FEBS letters 1994-07, Vol.348 (2), p.211-215
Main Authors: Ichas, François, Jouaville, Laurence S., Sidash, Sergueï S., Mazat, Jean-Pierre, Holmuhamedov, Ekhson L.
Format: Article
Language:English
Subjects:
Animals
Ant A, antimycin A
Calcium - metabolism
Calcium-induced calcium release
Cell calcium signalling
CICR, calcium-induced calcium release
Cyclosporin A
Cys A, cyclosporin A
ER, endoplasmic reticulum
Inositol triphosphate
InsP3, inositol triphosphate
Intracellular Membranes - metabolism
mCICR, mitochondrial calcium-induced calcium release
Mitochondria, Liver - metabolism
Mitochondrion
mPTP, mitochondrial permeability transition pore
Permeability
Permeability transition pore
PSC 833, SDZ PSC 833
Rats
Signal Transduction
TPP+, tetraphenylphosphonium
Tumor Cells, Cultured
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Summary:We report reversible Ca 2+-induced Ca 2+ release from mitochondria, which takes the form of Ca 2+ spikes. Mitochondrial Ca 2+ spiking is an all-or-none process with a threshold dependence on both the frequency and the amplitude of the Ca 2+ pulses used as stimuli. This spiking relies on the transient operation of the mitochondrial permeability transition pore, and is initiated — in a threshold-dependent manner — with inositol-triphosphate-mediated Ca 2+ responses in permeabilized cells. Evidence that mitochondrial Ca 2+-induced Ca 2+ release contributes to inositol-triphosphate-mediated Ca 2+ responses in intact cells is also reported.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(94)00615-6