Retro-Binding Tripeptide Thrombin Active-Site Inhibitors: Discovery, Synthesis, and Molecular Modeling

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Bibliographic Details
Published in:Journal of medicinal chemistry 1994-07, Vol.37 (14), p.2122-2124
Main Authors: Iwanowicz, Edwin J, Lau, Wan F, Lin, James, Roberts, Daniel G. M, Seiler, Steven M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Binding Sites
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Medical sciences
Models, Molecular
Molecular Sequence Data
Oligopeptides - metabolism
Pharmacology. Drug treatments
Serine Proteinase Inhibitors - chemical synthesis
Structure-Activity Relationship
Thrombin - antagonists & inhibitors
Thrombin - metabolism
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm00040a001