Viral Replication and Development of Specific Immunity in Macaques after Infection with Different Measles Virus Strains

Cynomolgus monkeys (Macaca fascicularis) were experimentally infected with a wild type measles virus (MY) strain (MY-BIL). Following intratracheal inoculation with different infectious doses, the virus could be isolated from peripheral blood mononuclear cells (PBMC), lung lavage cells, and pharyngea...

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Bibliographic Details
Published in:The Journal of infectious diseases 1994-08, Vol.170 (2), p.443-448
Main Authors: van Binnendijk, Robert S., van der Heijden, Roger W. J., Amerongen, Geert van, UytdeHaag, Fons G. C. M., Osterhaus, Albert D. M. E.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral - biosynthesis
Concise Communications
Disease Models, Animal
Humans
Immunity, Cellular
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Infections
Kinetics
Leukocytes, Mononuclear - microbiology
Lung - cytology
Lung - microbiology
Macaca fascicularis
Measles
Measles - immunology
Measles - microbiology
Measles virus
Measles virus - immunology
Measles virus - physiology
Monkeys
Pharynx - cytology
Pharynx - microbiology
T lymphocytes
T-Lymphocytes - immunology
Vaccination
Vero cells
Viremia
Viremia - immunology
Viremia - microbiology
Virus Replication
Viruses
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Summary:Cynomolgus monkeys (Macaca fascicularis) were experimentally infected with a wild type measles virus (MY) strain (MY-BIL). Following intratracheal inoculation with different infectious doses, the virus could be isolated from peripheral blood mononuclear cells (PBMC), lung lavage cells, and pharyngeal cells. The kinetics of the cell-associated viremia was similar in all infected animals. They developed specific serum IgM, IgG, and neutralizing antibody responses as well as MY-specific T cell-mediated immunity. Monkeys infected intratracheally or intramuscularly with the wild type MY-Edmonston or the attenuated MY-Schwartz strain showed a lower level of PBMC-associated viremia and less pronounced specific IgM responses. Nine months after infection with MY strains, all of the monkeys were protected from intratracheal reinfection with MY-BIL. This monkey model is suitable for study of new generations of vaccines and vaccination strategies for measles.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/170.2.443