Experiments with inactivated Visna-Maedi vaccine

Sixteen Icelandic sheep were vaccinated against Visna-Maedi infection with formalin inactivated whole virus vaccine to which alun was added as an adjuvant. Western Blots showed that all the vaccinees responded to the major proteins of the virus. They all developed neutralizing antibodies ranging in...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1994-06, Vol.724 (1), p.140-147
Main Author: Gudnadottir, M
Format: Article
Language:English
Subjects:
Animals
Antibodies, Viral - biosynthesis
Antibodies, Viral - immunology
ANTIGEN ANTIBODY REACTIONS
Blotting, Western - veterinary
Female
HUMORAL IMMUNITY
IMMUNITE HUMORALE
INACTIVATED VACCINES
INMUNIDAD HUMORAL
Male
Neutralization Tests - veterinary
OVIN
OVINOS
REACCION ANTIGENO-ANTICUERPO
REACTION ANTIGENE ANTICORPS
SHEEP
VACCIN
VACCINE DEVELOPMENT
VACCINES
Vaccines, Inactivated
VACUNA
Viral Vaccines - immunology
Viral Vaccines - therapeutic use
VIRUS NEUTRALIZATION
VIRUS VISNA MAEDI
Visna - prevention & control
VISNA MAEDI VIRUS
Visna-maedi virus - immunology
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Description
Summary:Sixteen Icelandic sheep were vaccinated against Visna-Maedi infection with formalin inactivated whole virus vaccine to which alun was added as an adjuvant. Western Blots showed that all the vaccinees responded to the major proteins of the virus. They all developed neutralizing antibodies ranging in titers from 1/8-1/256 at maximum for individual sheep. Passive transfer of antibodies and neutralizing activity from vaccinated ewes to their lambs was demonstrated. Exposure of the 16 vaccinees and their 16 unvaccinated control sheep to natural infection is attempted by housing them with heavily infected sheep. After 9 months of exposure there is no seroconversion in the unvaccinated group. Only time can tell, whether or not such conventional vaccination with inactivated vaccine protects the vaccinees.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1994.tb38902.x