HLA antigens in Arabs with lichen planus

Summary We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018,...

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Bibliographic Details
Published in:Clinical and experimental dermatology 1994-05, Vol.19 (3), p.236-237
Main Authors: WHITE, A.G., ROSTOM, A.I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Child
Dermatology
Female
HLA-DR Antigens - blood
HLA-DR1 Antigen - blood
HLA-DR5 Antigen - blood
Humans
Incidence
Kuwait
Lichen Planus - immunology
Male
Medical sciences
Middle Aged
Psoriasis. Parapsoriasis. Lichen
Tropical medicine
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Summary:Summary We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018, RR = 3.68) and HLA‐DRH) (P. corr. = 0.00096, RR=8.27) and a significant decrease in HLA DR5 (P. corr. = 0.0396, RR = 0.18.) The relevance of these findings to earlier reports on lichen planus in which HLA‐DR1 (but not DR10) is increased is discussed. This is the first report of HLA antigen frequency in Arab patients with lichen planus, and would support the fact that HLA DR1 is universally associated with the disease, although the more significant association appears to be with HLA‐DR10.
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.1994.tb01174.x