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HLA antigens in Arabs with lichen planus
Summary We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018,...
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| Published in: | Clinical and experimental dermatology 1994-05, Vol.19 (3), p.236-237 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4656-e241f9e5f52a86ad4efc63d75075de6456a546832be929a4d97250d3bfab6abc3 |
| container_end_page | 237 |
| container_issue | 3 |
| container_start_page | 236 |
| container_title | Clinical and experimental dermatology |
| container_volume | 19 |
| creator | WHITE, A.G. ROSTOM, A.I. |
| description | Summary
We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018, RR = 3.68) and HLA‐DRH) (P. corr. = 0.00096, RR=8.27) and a significant decrease in HLA DR5 (P. corr. = 0.0396, RR = 0.18.) The relevance of these findings to earlier reports on lichen planus in which HLA‐DR1 (but not DR10) is increased is discussed. This is the first report of HLA antigen frequency in Arab patients with lichen planus, and would support the fact that HLA DR1 is universally associated with the disease, although the more significant association appears to be with HLA‐DR10. |
| doi_str_mv | 10.1111/j.1365-2230.1994.tb01174.x |
| format | article |
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We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018, RR = 3.68) and HLA‐DRH) (P. corr. = 0.00096, RR=8.27) and a significant decrease in HLA DR5 (P. corr. = 0.0396, RR = 0.18.) The relevance of these findings to earlier reports on lichen planus in which HLA‐DR1 (but not DR10) is increased is discussed. This is the first report of HLA antigen frequency in Arab patients with lichen planus, and would support the fact that HLA DR1 is universally associated with the disease, although the more significant association appears to be with HLA‐DR10.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.1994.tb01174.x</identifier><identifier>PMID: 8033385</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Child ; Dermatology ; Female ; HLA-DR Antigens - blood ; HLA-DR1 Antigen - blood ; HLA-DR5 Antigen - blood ; Humans ; Incidence ; Kuwait ; Lichen Planus - immunology ; Male ; Medical sciences ; Middle Aged ; Psoriasis. Parapsoriasis. Lichen ; Tropical medicine</subject><ispartof>Clinical and experimental dermatology, 1994-05, Vol.19 (3), p.236-237</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4656-e241f9e5f52a86ad4efc63d75075de6456a546832be929a4d97250d3bfab6abc3</citedby><cites>FETCH-LOGICAL-c4656-e241f9e5f52a86ad4efc63d75075de6456a546832be929a4d97250d3bfab6abc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4084395$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8033385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WHITE, A.G.</creatorcontrib><creatorcontrib>ROSTOM, A.I.</creatorcontrib><title>HLA antigens in Arabs with lichen planus</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018, RR = 3.68) and HLA‐DRH) (P. corr. = 0.00096, RR=8.27) and a significant decrease in HLA DR5 (P. corr. = 0.0396, RR = 0.18.) The relevance of these findings to earlier reports on lichen planus in which HLA‐DR1 (but not DR10) is increased is discussed. This is the first report of HLA antigen frequency in Arab patients with lichen planus, and would support the fact that HLA DR1 is universally associated with the disease, although the more significant association appears to be with HLA‐DR10.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dermatology</subject><subject>Female</subject><subject>HLA-DR Antigens - blood</subject><subject>HLA-DR1 Antigen - blood</subject><subject>HLA-DR5 Antigen - blood</subject><subject>Humans</subject><subject>Incidence</subject><subject>Kuwait</subject><subject>Lichen Planus - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Tropical medicine</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqVkF1LwzAUhoMoc05_glBExJvOJCcfrRfC2OamFL1RvAxpm7rMrptNy7Z_b8vK7s1NIO9z3hwehG4IHpLmPCyHBAT3KYXmIQzZsIoxIZINdyeof4xOUR8Dlr4IIThHF84tMSZAJO-hXoABIOB9dD-PRp4uKvttCufZwhuVOnbe1lYLL7fJwhTeJtdF7S7RWaZzZ666e4A-n6cf47kfvc9exqPIT5jgwjeUkSw0PONUB0KnzGSJgFRyLHlqBONCcyYCoLEJaahZGkrKcQpxpmOh4wQG6O7QuynXv7VxlVpZl5i8WcKsa6ekEBgHnDfg4wFMyrVzpcnUprQrXe4VwarVpJaqdaFaF6rVpDpNatcMX3e_1PHKpMfRzkuT33a5donOs1IXiXVHjOGAQdhiTwdsa3Oz_8cCajydUBBNgX8osK4yu2OBLn-UkCC5-nqbqQl9jXgERM3gD3NokSs</recordid><startdate>199405</startdate><enddate>199405</enddate><creator>WHITE, A.G.</creator><creator>ROSTOM, A.I.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199405</creationdate><title>HLA antigens in Arabs with lichen planus</title><author>WHITE, A.G. ; ROSTOM, A.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4656-e241f9e5f52a86ad4efc63d75075de6456a546832be929a4d97250d3bfab6abc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dermatology</topic><topic>Female</topic><topic>HLA-DR Antigens - blood</topic><topic>HLA-DR1 Antigen - blood</topic><topic>HLA-DR5 Antigen - blood</topic><topic>Humans</topic><topic>Incidence</topic><topic>Kuwait</topic><topic>Lichen Planus - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WHITE, A.G.</creatorcontrib><creatorcontrib>ROSTOM, A.I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WHITE, A.G.</au><au>ROSTOM, A.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA antigens in Arabs with lichen planus</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>1994-05</date><risdate>1994</risdate><volume>19</volume><issue>3</issue><spage>236</spage><epage>237</epage><pages>236-237</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
We have HLA typed 50 Arab patients with cutaneous lichen planus who were resident in Kuwait and then compared the antigen incidence with 100 normal controls. There were no significant differences in the antigens of the HLA‐ABC loci but there was a significant increase in HLA‐DR1 (P= 0.0018, RR = 3.68) and HLA‐DRH) (P. corr. = 0.00096, RR=8.27) and a significant decrease in HLA DR5 (P. corr. = 0.0396, RR = 0.18.) The relevance of these findings to earlier reports on lichen planus in which HLA‐DR1 (but not DR10) is increased is discussed. This is the first report of HLA antigen frequency in Arab patients with lichen planus, and would support the fact that HLA DR1 is universally associated with the disease, although the more significant association appears to be with HLA‐DR10.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8033385</pmid><doi>10.1111/j.1365-2230.1994.tb01174.x</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 1994-05, Vol.19 (3), p.236-237 |
| issn | 0307-6938 1365-2230 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76600855 |
| source | Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Biological and medical sciences Child Dermatology Female HLA-DR Antigens - blood HLA-DR1 Antigen - blood HLA-DR5 Antigen - blood Humans Incidence Kuwait Lichen Planus - immunology Male Medical sciences Middle Aged Psoriasis. Parapsoriasis. Lichen Tropical medicine |
| title | HLA antigens in Arabs with lichen planus |
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