Determination of boldine in drug formulations by first-derivative synchronous spectrofluorimetry

A simple and sensitive method is proposed for the determination of boldine by first-derivative synchronous spectrofluorimetry based on its native fluorescence in 0.1 N sulphuric acid. The constant wavelength difference ( Δλ = λ cm - λ c chosen to optimize the determination is 90 nm. The linear conce...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 1994-03, Vol.12 (3), p.313-317
Main Authors: Vilchez, JoséLuis, Sánchez-Palencia, Gonzalo, Avidad, Ramiro, Navalon, Alberto
Format: Article
Language:English
Subjects:
Analysis
Aporphines - analysis
Aporphines - chemistry
Biological and medical sciences
Boldine
derivative spectroscopy
drug formulations
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Reference Standards
Sensitivity and Specificity
Spectrometry, Fluorescence
Sulfuric Acids
synchronous spectrofluorimetry
Tablets - chemistry
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Summary:A simple and sensitive method is proposed for the determination of boldine by first-derivative synchronous spectrofluorimetry based on its native fluorescence in 0.1 N sulphuric acid. The constant wavelength difference ( Δλ = λ cm - λ c chosen to optimize the determination is 90 nm. The linear concentration range of application is between 2.0 and 50.0 wg I- −1 of boldine. the detection limit 0.4 wg l −1 and the relative standard deviation at a concentration of 25 μg l −1 was 2.19%. The method has been satisfactorily applied to the determination of boldine in pharmaceutical formulations.
ISSN:0731-7085
1873-264X
DOI:10.1016/0731-7085(94)90005-1