Leukopheresis for treatment of psoriasis: is therapeutical benefit related to reduced activities of neutral proteinases of polymorphonuclear leukocytes?

Ten patients were treated with repeated leukophereses performed one to three times per week for 2-5 weeks. Two of the patients was cleared completely, four exhibited regression of more than one-half of the lesions, and four showed only a slight improvement. The therapy did not markedly affect the gr...

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Bibliographic Details
Published in:Archives of Dermatological Research 1985, Vol.278 (1), p.6-12
Main Authors: GLINSKI, W, BARSZCZ, D, JABŁONSKA, S, ZAREBSKA, Z, TIGAŁONOWA, M, JANCZURA, E
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cathepsin G
Cathepsins - blood
Dermatology
Endopeptidases - blood
Female
Humans
Leukapheresis
Male
Medical sciences
Middle Aged
Muramidase - blood
Neprilysin
Neutrophils - enzymology
Pancreatic Elastase - blood
Peroxidase - blood
Psoriasis - enzymology
Psoriasis - therapy
Psoriasis. Parapsoriasis. Lichen
Serine Endopeptidases
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Summary:Ten patients were treated with repeated leukophereses performed one to three times per week for 2-5 weeks. Two of the patients was cleared completely, four exhibited regression of more than one-half of the lesions, and four showed only a slight improvement. The therapy did not markedly affect the granulocyte count in peripheral blood, and the beneficial clinical response was not related to the number of polymorphonuclear leukocytes (PMNs) removed by leukophereses. During therapy, the activities of elastase, cathepsin G, lysozyme, and myeloperoxidase in PMNs were determined by spectrophotometry. PMNs isolated using a Haemonetics 30 blood-cell separator were about 50% deficient in these activities in comparison to cells obtained directly from peripheral blood. Thus, leukopheresis induces a marked degranulation of PMNs. Repeated leukophereses were found to generate significant variations in the activities of circulating PMN granule enzymes and in the levels of acid-soluble proteins. Remission or great improvement were observed in patients who, during therapy, exhibited decreased PMN elastase and cathepsin G activities, whereas a poor clinical response was accompanied by high enzymatic activities.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00412488