Altered Responsiveness of the Aorta of Hypertensive Rats to Histamine and Acetylcholine

This study investigates the response of the noradrenaline-contracted aorta of normotensive. renal-induced and spontaneously hypertensive rats to acetylcholine (ACh) and histamine. Aortae of the renal-induced hypertensive rats compared to the those of the normotensive rats were hypo-responsive to the...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1985, Vol.39(4), pp.551-553
Main Authors: SIM, Meng Kwoon, CHUA, Mui Eng
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Antihypertensive agents
Aorta, Thoracic - drug effects
Biological and medical sciences
Cardiovascular system
Endothelium - physiology
Histamine - pharmacology
Hypertension - physiopathology
Hypertension, Renal - physiopathology
In Vitro Techniques
Medical sciences
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Norepinephrine - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study investigates the response of the noradrenaline-contracted aorta of normotensive. renal-induced and spontaneously hypertensive rats to acetylcholine (ACh) and histamine. Aortae of the renal-induced hypertensive rats compared to the those of the normotensive rats were hypo-responsive to the two vasodilators, indicating that the sensitivity of the endothelial histamine and acetylcholine receptors is significantly lower. However, with the spontaneously hypertensive rats, the high blood pressure appears to affect only the histamine receptors.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.39.551