In Vivo Effect of Calcitriol on Calcium Transport and Calcium Binding Proteins in the Spontaneously Hypertensive Rat

The abnormal intestinal Ca transport reported in spontaneously hypertensive rats (SHR) has been attributed to decreased responsiveness to calcitriol. We reexamined this hypothesis by studying the calcitriol regulation of SHR duodenal calbindin-D9K and calmodulin and the relation of calcitriol to Ca...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1994-08, Vol.24 (2), p.176-182
Main Authors: Roullet, Chantal M, Roullet, Jean-Baptiste, Martin, Anne-Sophie, Mccarron, David A
Format: Article
Language:English
Subjects:
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Calbindins
Calcitriol - pharmacology
Calcium - metabolism
Calmodulin - analysis
Cardiology. Vascular system
Experimental diseases
Hypertension - metabolism
Intestinal Mucosa - metabolism
Ion Transport - drug effects
Male
Medical sciences
Rats
Rats, Inbred SHR
Rats, Inbred WKY
S100 Calcium Binding Protein G - analysis
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Summary:The abnormal intestinal Ca transport reported in spontaneously hypertensive rats (SHR) has been attributed to decreased responsiveness to calcitriol. We reexamined this hypothesis by studying the calcitriol regulation of SHR duodenal calbindin-D9K and calmodulin and the relation of calcitriol to Ca uptake by isolated enterocytes. SHR and normotensive Wistar-Kyoto (WKY) rats were injected with either 50 ng/d calcitriol (vit-D) or vehicle alone (control) for 3 days. Decreased calbindin-D9K (P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.24.2.176