Identification of an intrinsic platelet function defect in Spitz dogs

A recently identified intrinsic platelet function defect in 2 Spitz dogs is described. Both affected dogs had a history of chronic intermittent bleeding primarily from the nasal, oral, and gastrointestinal mucosa. Platelet aggregation in response to adenosine diphosphate (ADP), collagen, and platele...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1994-03, Vol.8 (2), p.93-98
Main Authors: Boudreaux, M.K, Crager, C, Dillon, A.R, Stanz, K, Toivio-Kinnucan, M
Format: Article
Language:English
Subjects:
Animals
BLOOD COAGULATION
Blood Platelet Disorders - diagnosis
Blood Platelet Disorders - veterinary
Blood Platelets - drug effects
Blood Platelets - metabolism
Blood Platelets - ultrastructure
CASE STUDIES
CHIEN
COAGULACION SANGUINEA
COAGULATION SANGUINE
DIAGNOSIS
DIAGNOSTIC
DIAGNOSTICO
Dog Diseases - diagnosis
DOGS
ESTUDIOS DE CASOS PRACTICOS
ETUDE DE CAS
Female
FLOW CYTOMETRY
HAEMORRHAGE
HEMORRAGIA
HEMORRAGIE
HEMORRHAGE
Male
PERRO
Platelet Aggregation - drug effects
PLATELET COUNT
Platelet Membrane Glycoproteins - metabolism
PLATELETS
Serotonin - metabolism
THROMBOCYTE
TROMBOCITOS
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Description
Summary:A recently identified intrinsic platelet function defect in 2 Spitz dogs is described. Both affected dogs had a history of chronic intermittent bleeding primarily from the nasal, oral, and gastrointestinal mucosa. Platelet aggregation in response to adenosine diphosphate (ADP), collagen, and platelet activating factor (PAF) was absent; however, platelet shape change did occur. Platelets aggregated in response to gamma thrombin, although a delayed onset and a reduced velocity of aggregation were present. Platelet 14C‐serotonin release was diminished in response to collagen and PAF. Glycoprotein Illa was detected on the surface of platelets by flow cytometry. Platelets were morphologically normal under light and electron microscopy. Two male Spitz dogs, related to one of the affected dogs, did not have a bleeding diathesis. Collagen‐induced platelet aggregation, however, was diminished in these 2 dogs. This platelet defect most closely resembles the defect described in Basset hounds.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1994.tb03204.x