STRUCTURE-ACTIVITY RELATIONSHIP AMONG POLYHYDRO DERIVATIVES OF TYLOSIN

Tetra-, hexa-and octahydro derivatives of tylosin were prepared by the reduction of the conjugated double bond and carbonyl groups. Hydrogenation of the diene did not change the in vitro antimicrobial activity of compounds, while reduction of carbonyls causes small or complete loss of activity.

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Bibliographic Details
Published in:Journal of antibiotics 1994/05/25, Vol.47(5), pp.581-587
Main Authors: NARANDJA, AMALIA, ŠUŠKOVIC, BOZIDAR, KELNERIC, ZELJKO, DJOKIC, SLOBODAN
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Magnetic Resonance Spectroscopy
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Structure-Activity Relationship
Tylosin - analogs & derivatives
Tylosin - chemistry
Tylosin - pharmacology
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Description
Summary:Tetra-, hexa-and octahydro derivatives of tylosin were prepared by the reduction of the conjugated double bond and carbonyl groups. Hydrogenation of the diene did not change the in vitro antimicrobial activity of compounds, while reduction of carbonyls causes small or complete loss of activity.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.47.581