Properties of the transient potassium currents in cerebellar granule cells

Macroscopic potassium currents were studied in cell-attached and inside-out patches from rat cerebellar granule cells. They were related with transient IA type potassium channels. Currents activated rapidly at potentials higher than -40 mV and did not inactivate completely. The magnitude of the curr...

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Bibliographic Details
Published in:Experimental brain research 1994-03, Vol.98 (2), p.298-304
Main Authors: ZEGARRA-MORAN, O, MORAN, O
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cells, Cultured
Central nervous system
Cerebellum - cytology
Cerebellum - drug effects
Cerebellum - metabolism
Cytoplasmic Granules - drug effects
Cytoplasmic Granules - metabolism
Electrophysiology
Fundamental and applied biological sciences. Psychology
Kinetics
Membrane Potentials - drug effects
Potassium Channels - drug effects
Potassium Channels - metabolism
Rats
Rats, Wistar
Vertebrates: nervous system and sense organs
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Summary:Macroscopic potassium currents were studied in cell-attached and inside-out patches from rat cerebellar granule cells. They were related with transient IA type potassium channels. Currents activated rapidly at potentials higher than -40 mV and did not inactivate completely. The magnitude of the current diminished when the membrane patches were excised. No differences in the activation and inactivation properties were found between patches in the integral cells and cell free membrane patches. A biophysical description of the currents is presented.
ISSN:0014-4819
1432-1106
DOI:10.1007/BF00228417