Immunogenicity and Antigenicity of Infectious Bursal Disease Virus Serotypes I and II in Chickens

• Published in: Avian diseases 1985-10, Vol.29 (4), p.1184-1194
• Main Authors: Jackwood, D. J., Saif, Y. M., Moorhead, P. D.
• Format: Article
• Language: English
• Subjects: Animals; Antibodies; Antigen-Antibody Complex; Antigens; Antigens, Viral - analysis; Chickens; Cross Reactions; Geometric mean; Infectious bursal disease virus; Infectious bursal disease virus - classification; Infectious bursal disease virus - immunology; Inoculation; Inoculum; Lesions; Reoviridae - immunology; Reoviridae Infections - immunology; Serotyping; Vaccines; Viral diseases; Viruses
• ISSN: 0005-2086; 1938-4351
• DOI: 10.2307/1590472

Chickens were inoculated with infectious bursal disease virus serotype I or serotype II to determine if their immune system can distinguish between the two serotypes. Chickens had neutralizing antibodies to only serotype I viruses following exposure to serotype I viruses, and chickens had antibodies to only serotype II viruses following exposure to serotype II viruses. No cross-reactions were observed between antisera prepared to each of these two serotypes using a cross-virus-neutralization assay. Signs of disease were detected only in birds exposed to a virulent serotype I isolate. Chicks exposed to the serotype II viruses were not protected from challenge with a virulent serotype I isolate. In one experiment, antibodies to a serotype II isolate, which were detected before challenge, did not protect chicks from challenge with a virulent serotype I isolate. /// Con el objeto de determinar si el sistema inmunológico del pollo puede diferenciar entre los serotipos I y II del virus de la infección de la bolsa de fabricio, se inocularon pollos con estos virus. Se encontraron anticuerpos neutralizantes solo del serotipo I en los pollos expuestos a este serotipo; así mismo, se encontraron anticuerpos solo del serotipo II después de la inoculación de las cepas MO u OH pertenecientes a este serotipo. Usando pruebas de virus-neutralización, no se observaron reacciones cruzadas entre los antisueros preparados para cada uno de estos dos serotipos. Se detectaron signos de la enfermedad solamente en las aves inoculadas con la cepa virulenta identificada como ST-C que corresponde al serotipo I. Los pollos inoculados con el serotipo II no fueron protegidos frente al desafío con la cepa virulenta ST-C del serotipo I. En un experimento, los anticuerpos OH que fueron detectados antes del desafío, no protegieron a los pollos frente al desafío con el virus ST-C.