Influence of manganese deficiency on the characteristics of proteoglycans of avian epiphyseal growth plate cartilage

The need for manganese for normal skeletal development appears to be related to its role in proteoglycan biosynthesis. The purpose of this research was to characterize the proteoglycans synthesized under conditions of manganese deficiency. The proteoglycans were extracted from epiphyseal growth plat...

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Bibliographic Details
Published in:Poultry science 1994-05, Vol.73 (5), p.663-669
Main Authors: Liu, A.C.H, Heinrichs, B.S, Leach, R.M. Jr
Format: Article
Language:English
Subjects:
AMINOAZUCARES
AMINOSUCRE
Animals
CARENCE MINERALE
CARTILAGE
CARTILAGO
Chickens
DEFICIENCIA DE MINERALES
DESARROLLO DEL ESQUELETO
DEVELOPPEMENT DU SQUELETTE
Growth Plate - chemistry
HUESOS
INDICE DE CRECIMIENTO
Male
MANGANESE
Manganese - deficiency
MANGANESO
POLLITO
POUSSIN
PROTEOGLICANOS
PROTEOGLYCANE
Proteoglycans - chemistry
Proteoglycans - isolation & purification
TAUX DE CROISSANCE
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Summary:The need for manganese for normal skeletal development appears to be related to its role in proteoglycan biosynthesis. The purpose of this research was to characterize the proteoglycans synthesized under conditions of manganese deficiency. The proteoglycans were extracted from epiphyseal growth plate cartilage and the monomers separated by cesium chloride density gradient centrifugation followed by column chromatography. The proteoglycan monomers from normal cartilage contained primarily (92%) chondroitin sulfate side chains with keratan sulfate being a minor (8%) component. Manganese deficiency reduced the total amount of cartilage proteoglycans. Of the monomers present in deficient cartilage, the majority (75%) were similar to those found in normal cartilage. Cartilage from deficient chicks also contained a second monomer fraction (25%) characterized by a reduced carbohydrate content. Thus, in addition to a reduction in total proteoglycan content, manganese deficiency results in qualitative changes in the proteoglycans present in epiphyseal growth plate cartilage
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.0730663