The beneficial effects of aminophylline administration on heparin reversal with protamine

The aim of this study was to demonstrate the beneficial effects of aminophylline on protamine cardiotoxicity. Thirty-four patients were examined, 17 of whom received aminophylline 3 mg/kg before protamine administration, being the study group, while the other 17, being the control group, did not. Al...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 1994-01, Vol.24 (2), p.99-102
Main Authors: KATIRCIOGLU, S. F, SÜHA KÜCÜKAKSU, D, BOZDAYI, M, DALVA, K, BINALI MATIVAS, ZORLUTUNA, Y, TASDEMIR, O, BAYAZIT, K
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - blood
Adult
Aminophylline - administration & dosage
Aminophylline - therapeutic use
Biological and medical sciences
Coronary Artery Bypass
Drug toxicity and drugs side effects treatment
Heart - drug effects
Hemodynamics - drug effects
Heparin - administration & dosage
Heparin - adverse effects
Heparin - therapeutic use
Humans
Medical sciences
Middle Aged
Myocardium - metabolism
Oxygen Consumption
Pharmacology. Drug treatments
Preoperative Care
Protamines - administration & dosage
Protamines - adverse effects
Protamines - therapeutic use
Toxicity: cardiovascular system
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Summary:The aim of this study was to demonstrate the beneficial effects of aminophylline on protamine cardiotoxicity. Thirty-four patients were examined, 17 of whom received aminophylline 3 mg/kg before protamine administration, being the study group, while the other 17, being the control group, did not. All cardiac output and biochemical measurements were evaluated 5 min following protamine administration. The cAMP level was 43.4 +/- 3.51 pmol/ml in the study group and 18.7 +/- 2.98 in the control group (P < 0.0001) before protamine administration, while the oxygen extraction rate decreased from 49% to 44 +/- 2% in the control group, and from 51.2% to 47 +/- 3% in the study group (P < 0.03). The N-acetyl glucosaminidase value was 16.9 +/- 13.9 pmol/ml in the study group and 27.8 +/- 1.47 pmol/ml in the control group (P < 0.01), and myocardial lactate extraction was -0.20 +/- 0.03 in the control group and -0.07 +/- 0.07 in the study group (P < 0.001). The left ventricular stroke work index was 28.6 +/- 3.14 gm/m2 in the control group and 37 +/- 6.77 gm/m2 in the study group (P < 0.002). The findings of this study led us to conclude that the adverse effects of heparin neutralization using protamine can be relieved by aminophylline.
ISSN:0941-1291
1436-2813
DOI:10.1007/BF02473388