TISSUE PENETRATION OF AZTREONAM IN OBSTETRICS AND GYNECOLOGY

The following results were obtained by measuring serum and tissue concentrations of aztreonam, a new monobactam antibiotic. 1. Penetration into each tissue was favorable, particularly, to the portio vaginalis, but there was no conspicuous difference of the penetration among other tissues. 2. Serum c...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1985/12/25, Vol.38(12), pp.3606-3608
Main Authors: TAKABAYASHI, HARUO, KUWABARA, SORYU
Format: Article
Language:Japanese
Subjects:
Adult
Aztreonam - administration & dosage
Aztreonam - blood
Aztreonam - metabolism
Female
Genitalia, Female - metabolism
Humans
Injections, Intravenous
Middle Aged
Tissue Distribution
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Description
Summary:The following results were obtained by measuring serum and tissue concentrations of aztreonam, a new monobactam antibiotic. 1. Penetration into each tissue was favorable, particularly, to the portio vaginalis, but there was no conspicuous difference of the penetration among other tissues. 2. Serum concentration tended to decrease with the lapse of time, but the concentration in each tissue did not show a specific pattern of change due to a considerable irregularity of the measured concentrations. 3. No specific side effect was noted.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.38.3606