Effect of levamisol on cellular and humoral immune reactivity and on recurrences in patients with bladder papilloma

Ten patients who had undergone repeated surgical interventions for bladder papilloma with successive recurrences within intervals of a few months, were given levamisol in weekly doses of 300 mg over a year, and were followed up for various cellular immune reactions, as well as for serum globulin and...

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Bibliographic Details
Published in:International urology and nephrology 1985-12, Vol.17 (4), p.323-330
Main Authors: Romics, I, Horváth, J, Fehér, J, Csontai, A
Format: Article
Language:English
Subjects:
Aged
Female
Humans
Immunoglobulin G - metabolism
Immunotherapy - methods
Leukocyte Count
Levamisole - therapeutic use
Lymphocyte Activation - drug effects
Male
Middle Aged
Neoplasm Recurrence, Local - prevention & control
Papilloma - immunology
Papilloma - therapy
Rosette Formation
Tuberculin Test
Urinary Bladder Neoplasms - immunology
Urinary Bladder Neoplasms - therapy
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Summary:Ten patients who had undergone repeated surgical interventions for bladder papilloma with successive recurrences within intervals of a few months, were given levamisol in weekly doses of 300 mg over a year, and were followed up for various cellular immune reactions, as well as for serum globulin and for acute-phase protein concentrations in the course of treatment. Levamisol was found to act primarily on cell-borne responsiveness. The recurrence-free intervals increased in the course of treatment. Four patients have remained free from recurrences since the start of treatment.
ISSN:0301-1623
1573-2584
DOI:10.1007/BF02083502