Functional nuclear suppressor of mitochondrial oxi2 mutations in yeast

A semidominant nuclear suppressor, called nam6, of oxi2-V276 mitochondrial mutation has been isolated and characterized. The nuclear character of nam6 was proved by its retention in rho degree strains, lack of mitotic segregation in diploids and meiotic 2:2 segregation in tetrads. The specificity of...

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Bibliographic Details
Published in:Current genetics 1985-01, Vol.10 (2), p.87-93
Main Authors: KRUSZEWSKA, A, SZCZESNIAK, B
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
DNA, Fungal - genetics
DNA, Mitochondrial - genetics
Electron Transport Complex IV - biosynthesis
Electron Transport Complex IV - genetics
Fundamental and applied biological sciences. Psychology
Genes, Fungal
Genetics of eukaryotes. Biological and molecular evolution
Saccharomyces cerevisiae
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Suppression, Genetic
Thallophyta, bryophyta
Vegetals
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Summary:A semidominant nuclear suppressor, called nam6, of oxi2-V276 mitochondrial mutation has been isolated and characterized. The nuclear character of nam6 was proved by its retention in rho degree strains, lack of mitotic segregation in diploids and meiotic 2:2 segregation in tetrads. The specificity of nam6 was tested on 315 mit- mutations of four mitochondrial genes (oxi1, oxi2, oxi3, and cob-box). It suppresses clearly only three mutations in the oxi2 gene, restoring partially or completely cytochrome aa3 formation. The results suggest a functional character of the suppression.
ISSN:0172-8083
1432-0983
DOI:10.1007/BF00636472