Rat brain Na + channel mRNAs in non-excitable Schwann cells

The expression of rat brain voltage-sensitive Na + channel mRNAs in Schwann cells was examined using in situ hybridization cytochemistry and RT-PCR. The mRNAs of rat brain Na + channel subtype II and III, but not subtype I, were detected in cultured Schwann cells from sciatic nerve and in intact sci...

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Bibliographic Details
Published in:FEBS letters 1994-08, Vol.350 (2), p.342-346
Main Authors: Oh, Youngsuk, Black, Joel A., Waxman, Stephen G.
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
CNS, central nervous system
Gene Expression
Glial cell
In Situ Hybridization
In Vitro Techniques
Ion channel
PNS, peripheral nervous system
Rats
Rats, Sprague-Dawley
RNA Probes
RNA, Messenger - genetics
RT-PCR, reverse transcription-polymerase chain reaction
Schwann Cells - physiology
Sciatic nerve
Sciatic Nerve - physiology
Sodium Channels - physiology
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Summary:The expression of rat brain voltage-sensitive Na + channel mRNAs in Schwann cells was examined using in situ hybridization cytochemistry and RT-PCR. The mRNAs of rat brain Na + channel subtype II and III, but not subtype I, were detected in cultured Schwann cells from sciatic nerve and in intact sciatic nerve, which contains Schwann cells but not neuronal cell bodies. These results indicate that rat brain Na + channel mRNAs, which have been considered as mainly neuronal-type messages, are also expressed in glial cells in vitro and in vivo.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(94)00807-8