Glycosaminoglycan in malignant pleural mesothelioma

The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical methods. In the tumor tissues, it was found that the average of the total amount of GAG wa...

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Bibliographic Details
Published in:Cancer 1986-01, Vol.57 (1), p.106-110
Main Authors: Nakano, Takashi, Fujii, Junji, Tamura, Shinsuke, Amuro, Yoshiki, Nabeshima, Kenji, Horai, Takeshi, Hada, Toshikazu, Higashino, Kazuya
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Female
Glycosaminoglycans - analysis
Humans
Hyaluronic Acid - analysis
Male
Medical sciences
Mesothelioma - analysis
Middle Aged
Pleura - analysis
Pleural Neoplasms - analysis
Pneumology
Tumors of the respiratory system and mediastinum
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Summary:The quantitative analysis on glycosaminoglycan (GAG) in the tumor tissues of five patients with malignant pleural mesothelioma and in the pleural fluid of two patients was performed with the use of biochemical methods. In the tumor tissues, it was found that the average of the total amount of GAG was more than 7.9 times as high as that in adenocarcinoma of the lung, and that hyaluronic acid and chondroitin sulfate were main constituents of mesothelioma GAG. However, there was no significant difference in the content of dermatan sulfate and heparan sulfate between this neoplasm and adenocarcinoma. In the pleural fluid, the amount of hyaluronic acid was about 40 to 230 times higher than that in adenocarcinoma of the lung with the increment of chondroitin sulfate (11–87 times). These findings suggest that a marked increase in the total amount of GAG and the elevation of either the hyaluronic acid or the chondroitin sulfate level, or both, are characteristic abnormalities in malignant pleural mesothelioma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19860101)57:1<106::AID-CNCR2820570122>3.0.CO;2-C