Mutation of an mutL Homologue in a Navajo Family With Hereditary Nonpolyposis Colorectal Cancer

Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of inherited colon cancer, and it may represent the most frequent hereditary cancer-prone disorder. Research into a Navajo family with this disease is discussed.

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1994-09, Vol.86 (18), p.1417-1419
Main Authors: Lynch, Henry T., Drouhard, Thomas, Lanspa, Stephen, Smyrk, Thomas, Lynch, Patrick, Lynch, Jane, Vogelstein, Bert, Nyströ-Lathi, Minna, Sistonen, P., Peltomäki, Päivi, de la Chapelle, Albert
Format: Article
Language:English
Subjects:
Biological and medical sciences
Colon cancer
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
DNA, Neoplasm - genetics
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Indians, North American
Medical research
Medical sciences
Mutation
Native Americans
Pedigree
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Description
Summary:Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of inherited colon cancer, and it may represent the most frequent hereditary cancer-prone disorder. Research into a Navajo family with this disease is discussed.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/86.18.1417