CLINICAL EFFECT OF ARBEKACIN ON MRSA INFECTIONS AFTER GASTROINTESTINAL SURGERY

From January 1991 to July 1993, 58 patients with MRSA infections in our clinic at Wakayama Medical College and six affiliated hospitals were administered with arbekacin (ABK). The clinical results were as follows: 1. The clinical efficacy rates of ABK were 84% in pneumonia, 100% in both wound infect...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1994/06/25, Vol.47(6), pp.837-843
Main Authors: OCHIAI, MINORU, TANIMURA, HIROSHI, NOGUCHI, KOUHEI, TAKIFUJI, KATSUYA, KONISHI, RYUZOU, OHKOUCHI, NORIHITO, KOUNO, NOBUJI, OHNISHI, HIRONOBU, SHIMADA, KOUSUKE, KASITANI, MASUO, FUKIAGE, OSAMU, URA, SHINZOU, JOUHATA, KIYOFUMI, KOBAYASHI, YASUTO, DOUNISHI, HIROKI, AOKI, YOZO
Format: Article
Language:Japanese
Subjects:
Administration, Inhalation
Administration, Topical
Aminoglycosides
Anti-Bacterial Agents
Dibekacin - administration & dosage
Dibekacin - analogs & derivatives
Dibekacin - therapeutic use
Drug Evaluation
Drug Therapy, Combination - therapeutic use
Gastrointestinal Diseases - surgery
Humans
Infusions, Intravenous
Methicillin Resistance
Postoperative Complications - drug therapy
Staphylococcal Infections - drug therapy
Staphylococcus aureus - drug effects
Surgical Wound Infection - drug therapy
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Summary:From January 1991 to July 1993, 58 patients with MRSA infections in our clinic at Wakayama Medical College and six affiliated hospitals were administered with arbekacin (ABK). The clinical results were as follows: 1. The clinical efficacy rates of ABK were 84% in pneumonia, 100% in both wound infections and hepatobiliary tract infections, and 85% in total. The bacteriological efficacy rate was 83%. 2. Regarding the administration route, the clinical efficacy rates were 60-79% by the intravenous treatment and inhalation therapy. Especially by the local administration with ABK, MRSA was eradicated in all cases. 3. The sufficient efficacy was obtained by the treatment of ABK alone (89%) and by the combined treatment with ABK (82%) and another antibiotics. From these results, it is concluded that ABK is useful for the treatment of MRSA infections after gastrointestinal surgery.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.47.837