Autocrine, paracrine, and hormonal signals involved in growth plate chondrocyte differentiation

Longitudinal bone growth depends upon intricate steps in the metabolism and differentiation of epiphyseal growth plate chondrocytes. These steps involve cell proliferation followed of gene products that are characteristic of the subsequent stages of differentiation. Until recently, the major control...

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Bibliographic Details
Published in:Poultry science 1994-06, Vol.73 (6), p.883-888
Main Authors: Leach, R.M, Twal, W.O
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - drug effects
CELLULE
CELULAS
Chickens
CRECIMIENTO
CROISSANCE
CULTIVO DE CELULAS
CULTIVO DE TEJIDOS
CULTURE DE CELLULE
CULTURE DE TISSU
FACTEUR DE CROISSANCE IGF
FACTOR DE CRECIMIENTO IGF
FORMACION OSEA
FORMATION DES OS
Growth Hormone - pharmacology
Growth Plate - cytology
Growth Plate - drug effects
Growth Substances - analysis
Growth Substances - pharmacology
HORMONAS
HORMONE
HUESOS
Immunohistochemistry
In Situ Hybridization
Parathyroid Hormone - pharmacology
PEPTIDE
PEPTIDOS
POLLO
POULET
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Summary:Longitudinal bone growth depends upon intricate steps in the metabolism and differentiation of epiphyseal growth plate chondrocytes. These steps involve cell proliferation followed of gene products that are characteristic of the subsequent stages of differentiation. Until recently, the major control of growth plate metabolism was to reside with systemic hormones, principally growth hormone. However, it is now apparent that locally produced peptide growth factors play important autocrine and paracrine roles in normal growth plate physiology. Investigations with cultured chondrocytes have demonstrated the importance of the peptide growth factors insulin-like growth factor-I, transforming growth factor-beta and basic fibroblast growth factor for cell proliferation, extracellular matrix biosynthesis, and changes in morphology associated with the progressive stages of chondrocyte differentiation. All three of these factors have been shown to be present in specific zones of the epiphyseal growth plate. A preliminary map of the epiphyseal growth plate is proposed, which delineates the site and mode of action of systemic and locally produced factors involved in longitudinal bone growth
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.0730883