Effect of age of initiation of feed restriction on growth, body composition, and longevity of rats

Male Wistar rats were maintained on four dietary regimens: fed ad libitum throughout life (A); fed intermittently either during the first year of life and ad libitum thereafter (RA) or vice versa (AR); and fed intermittently throughout life (R). Low body weights, low amounts of body components (prot...

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Published in:Journal of gerontology (Kirkwood) 1986-01, Vol.41 (1), p.13-19
Main Authors: Beauchene, R E, Bales, C W, Bragg, C S, Hawkins, S T, Mason, R L
Format: Article
Language:English
Subjects:
Aging
Animals
Body Composition
Body Weight
Diet
Longevity
Male
Rats
Rats, Inbred Strains - growth & development
Weaning
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container_title Journal of gerontology (Kirkwood)
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creator Beauchene, R E
Bales, C W
Bragg, C S
Hawkins, S T
Mason, R L
description Male Wistar rats were maintained on four dietary regimens: fed ad libitum throughout life (A); fed intermittently either during the first year of life and ad libitum thereafter (RA) or vice versa (AR); and fed intermittently throughout life (R). Low body weights, low amounts of body components (protein, fat, moisture, and ash), and long life spans were observed in R. AR and RA lost or gained body weight, respectively, after dietary transfer and lived longer than A. Maximum body weight and the age at which it was attained were correlated positively with life span in A. Predicted mature body weight was correlated negatively with life span in R. RA and AR differed in growth and body composition, but their life spans were similar and intermediate to those of A and R. Increases in life span were obtained by intermittent feeding during all or part of the life span, but growth and body composition data did not consistently explain the mechanism of this effect.
doi_str_mv 10.1093/geronj/41.1.13
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source Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects Aging
Animals
Body Composition
Body Weight
Diet
Longevity
Male
Rats
Rats, Inbred Strains - growth & development
Weaning
title Effect of age of initiation of feed restriction on growth, body composition, and longevity of rats
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